• by KnuthIsGod on 6/23/2025, 2:04:44 AM

    Funded by Vertex Pharmaceuticals, the company that is trying to sell this treatment...

    Vertex Pharmaceuticals early investors stand to benefit.

    Patients not so much...

    "Two deaths occurred — one caused by cryptococcal meningitis and one by severe dementia with agitation"

    "Neutropenia was the most common serious adverse event, occurring in 3 participants. "

    So two of 12 died..

    Another three has significant neutropenia.

    Vertex have a bit of a track record:

    https://www.biospace.com/policy/hhs-says-vertex-is-grasping-...

    "Along with its gene editing therapy Casgevy, Vertex is offering fertility preservation support for its patients—a program that the HHS claims violates anti-kickback statutes."

    "Vertex sued the HHS in July 2024 after the department's Office of the Inspector General (OIG) decided not to issue a favorable opinion on the company's fertility support for Casgevy patients. "

  • by mikequinlan on 6/23/2025, 12:22:05 AM

    Yes, cured but…

    >But patients in the trial had to stay on drugs to prevent the immune system from destroying the new cells. Suppressing the immune system, he said, increases the risk of infections and, over the long term, can increase the risk of cancer.

    >“The argument is this immunosuppression is not as dangerous as what we typically use for kidneys, hearts and lungs, but we won’t know that definitely for many years,” Dr. Hirsch said.

    >Patients may have to take the immunosuppressant drugs for the rest of their lives, the Vertex spokeswoman said.

    https://www.nytimes.com/2025/06/20/health/diabetes-cure-insu...

  • by gnabgib on 6/23/2025, 12:18:14 AM

    Article title: Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes

    n=14, 2 died during the study, 10 had insulin independence (the paper does not say cured).

    Funding conflict: Funded by Vertex Pharmaceuticals (the makers of the cell–derived islet-cell therapy)

  • by bix6 on 6/23/2025, 2:20:27 AM

    There are better options in development. Immunosuppressants are not something that most T1Ds I know are willing to take.

  • by crawsome on 6/23/2025, 2:34:17 AM

    "Cured" seems to be words chosen by OP.