Of note from the "Acknowledgements" section:

> K.C. is a director of TdeltaS Ltd., a company spun out of the University of Oxford to develop products based on the science of ketone bodies in human nutrition.

Doing keto long enough however, your kidneys might wear out before your brain

I initially tried keto just to lose weight. But to my surprise, after about three weeks, I started feeling much clearer mentally, and overall just lighter, like something had lifted.

Back then, I thought it was just a coincidence. Now, reading this paper, I’m starting to think it might really have something to do with how the brain gets its energy.

I'm not sure I understand the method.

Is it correct that the study looked at the effect of a single (large) dose of ketones, rather than ongoing consumption?

As I understand it, dosage was 0.395g per kilo of body weight (so about 27g for 70kg subject), and that was it - with measurements of brain activity before and after.

No indication of duration of effect?

I Googled and have found a product on Amazon, which is asking about 30 USD for that dose, which would make daily 900 USD a month (!)

What are those supplements as I find a keto diet impossible to maintain.

Absolutely terrible science, the conclusion is a bunch of mechanistic speculation passed off as causal inference, just more keto bro grifters trying to pretend to be scientists.

Can someone give me a TL;DR?

You can also get ketones in nail polish removers.

“Ketones, whether produced endogenously through fasting or low-carbohydrate/high-fat diets or administered exogenously as a supplement, have been shown to improve age-related cognitive decline (23–25) and to restore insulin-resistance-induced deficits in axonal conduction velocity” - Another win for the gym bros