Several members of my family and I have used 23AndMe. It's interesting. I haven't logged into the site since about a week or two after getting it, but the health stuff was interesting (didn't really learn anything new but it was cool). The ancestry portion is the biggest appeal for most people, and my mom gets a kick out of it as she's into genealogy.

On the other hand, where it was a novelty for my family, it has ruined others... so make sure it's a door you want to open. ;)

For my family, the heritage was a bit educational, though it often felt a bit like wrong guesses (if you're 25% English, 25% Scottish, 25% Welsh, 25% Irish, you'll come back 100% "British Isles"). My spouse's 25% Native American data was even worse, about 1/8 of it coming in as "East Asian".

Finding specific gene data was also cool, but disappointing. If you know that a certain gene is defective, there's no way of knowing if your C should be a G, and a lot of gene markers aren't even findable. It's like a mostly-complete index for a book that's 25% written, and 5% of that is flat out wrong. So the health stuff was disappointing. I do feel, though, that obtaining the service was a step in the right direction for the industry someday getting this right.

As it gains critical mass, it's a great resource for connecting with second cousins as, if your family is like mine, older generations grew apart and want to reconnect.

23andme and similar have a horrible track record of privacy... I would highly suggest against using a service that combines the sequencing and the analysis. I would suggest, however, if you are interested in this line of data based health investigation, to have the sequencing done by someone good at sequencing and then have analysis done separately (or in conjunction between the third party analyzer and the sequencer). The cost would be more, but with a smaller shop you are much more likely to be able to request stringent data secrecy or even deletion.

I say this as a person who sysadminned a genetics lab, so my scientific knowledge of the subject is limited, but I did see the practical issues around the industry.

I read that they sell your information. You could try using a different name, if possible. However, be ware that they might do some type of data consolidation with other services in the future. For instance, a service you do at a hospital in 6 years could help uncover your identity because that hospital uses a third party. I mean, it could potentially even affect your health insurance 10 years from now.

I thought it was interesting but didn't result in my learning some information that I can actually act on. I extracted my data from the site and instead of just using their own site analysis tools I uploaded it to some third party analyzers, which provided more detailed information that 23andme is either not willing or not allowed by regulations to share. All of my health findings were "good news" that made me feel nice, even though I know they are to be taken with a big grain of salt.

been using Nylas Mail. Works pretty well. https://www.nylas.com/nylas-mail/